Lynparza [Olaparib} - Olaparib 50mg | MillionHealthPharma

Olaparib 50mg

DESCRIPTION

Olaparib 50mg is a generic form of brand name Lynparza. Which is required for some types of ovarian cancer that have come back after treatment. It is for people whohave a alter in a gene called BRCA and have had a variety of chemotherapy called platinum Lynparza which used asprescription drug which used under the supervision of medical practioners .

Olaparib 50mg

INDICATION

Lynparza is an antitumor medication which is Indicated for the treatment in patients with advanced ovarian cancer Indicated for the treatment in patients with HER2 – negative metastatic breast cancer. 

Olaparib 50mg

MECHANISM OF ACTION

Olaparib 50mg belongs to poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, containing PARP1, PARP2, and PARP3. PARP enzymes are included in DNA transcription, cell cycle managing, and DNA repair. Olaparib consist of anefficient oral PARP inhibitor thatactivates synthetic lethality in BRCA1/2 deficient cancer cells via the formation of double-stranded DNA breaks that cannot be exactly repaired, which causesinterruption of cellular homeostasis and cell death .

ADME

High plasma concentration 1 to 3 hours

plasma protein binding is 82%

Volume of distribution 167 +/-196 L

Primarily metabolised by CYP3A4

Excreted via urine 44% and 42% through the feces.

Lynparza Half – life is 11.9 hours

Finishing of 2 years of treatment :

• Full response of drug to patients (no radiologic evidence): discontinue treatment

• Patients with symptoms of disease and may asset from continuous treatment treat beyond 2 years.

DOSAGE MANAGEMENT

Ovarian cancer :

Maintenance treatment of relapsed ovarian cancer

The tablet prescribed dose is 300mg (two 150mg – mg tablets) PO BID

Follow treatment until disease progression or unacceptable toxicity

Single treatment for advanced BRCA – mutated ovarian cancer

The tablet prescribed dose is 300mg (two 150mg – mg tablets) PO BID

The capsules recommended dose is 400mg (eight 50mg- mg capsules) PO BID

Follow treatment until disease progression or unacceptable toxicity.

Support treatment for advanced BRCA-mutated ovarian cancer

The tablet prescribed dose is 300mg administer two 150mg – mg tablets PO BID

Continue the therapy until disease progression, undesirable toxicity or completion of 2 years of treatment 

Olaparib 50mg

PRECAUTIONS

While on therapy with drug will causeHaematological toxicity in patientsincluding diagnoses or findings of commonly mild or moderate anaemia, neutropenia, thrombocytopenia and lymphopenia.
Monotherapy administration of Lynparza to patient the incidence of myelodysplastic syndrome will occur.
On basis of mechanism of action (PARP inhibition), Lynparza could cause fetal harm when administered to a pregnant woman.
Lynparza concomitant use with strong or moderate CYP3A inhibitors is not recommended.

SIDE EFFECTS

Common side effects for patients taking Olaparib :

• Musculoskeletal pain

• Diarrhea

• Decreased platelet count

• Decreased Haemoglobin

• Nausea

• Decreased white blood cell count

• Abdominal pain

• Vomiting

• Upper respiratory tract infection

• Anemia

• Decreased neutrophils

• Fatigue (including weakness)

• Increased serum creatinine

Less common side effects of patients administrating Olaparib :

• Vertigo

• Constipation

• Urinary tract infection

• Heartburn

• Decreased appetite

• Shortness of breath

• Myalgia

• Headache

• Skin rash

• Back pain

• Taste changes

• Cough

• Swelling 

Olaparib 50mg

PREGNANCY

Pregnancy category D: Based on Lynparza Pharmacological action, the drug causes fetal harm may occur when administrated to a pregnant woman.

LACTATION

The drug has no data available on the presence of Lynparza in human milk, hence avoid breast feeding during the treatment.

STORAGE

Store at 20°C to 25°C

MISSED DOSE

If dose is missed, then have the dose immediately before next dose timing reaches or swap the missed dose and continue the regular schedule.
Must Consult doctors regarding missed dose.

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