Sorafenib [Sorafenat ] - Sorafenat 200mg ; MillionHealthPharma

SORAFENAT

DESCRIPTION

Sorafenib sold under the brand name Sorafenat.Sorafenat 200mg belongs to the group of tyrosine kinase inhibitor or inhibitor of angiogensis. The drug is a type of targeted therapy Sorafenat is a prescription drug used under the supervision of health care provider.

                                                          

Sorafenat 200mg

                                                             
                                                       

INDICATION

Sorafenat 200mg tablet is a anticancer drug and indicated for the treatment of some condition as Advanced renal cell carcinoma Hepatocellular carcinoma Metastatic thyroid carcinoma
DOSAGE
                                                           

IN RENAL CELL CARCINOMA

The dose of Sorafenat 200mg is given as 400mg should be taken orally as twice daily for at least one hour before or two hours after the meal
                                                       

Sorafenat 200mg

THYROID CARCINOMA

The dose of Sorafenat is given as 400mg should be taken orally as twice daily for at least one hour before or two hours after the meal
                                                             

Sorafenat 200mg

HEPATOCELLULAR CARCINOMA

The usual dose of Sorafenat is given as 400mg should be taken orally as twice daily for at least one hour before or two hours after the meal.
                                            

Sorafenat 200mg

SORAFENAT WORKS IN THE BODY

Sorafenat includes in deficiency of tumor cell multiplication Sorafenat 200mg interfere with multiple intracellular and cell surface kinase These enzymes are specific for tumor cell signaling, angiogenesis and apoptosis. Sorafenat 200mg causes to reduce the blood flow to the cancer cells By prohibiting these enzymes (kinase), genetic transcription includes in cell proliferation and angiogenesis is blocked.

DRUG INTERACTION

Interaction of Sorafenat 200mgwith Rifampin a strong CYP3A4 inducer, administered at a dose of 600mg single use for 5 days with Sorafenat 200mg tablet causes decrease AUC of Sorafenib Interaction with neomycin will reduce the AUC of Sorafenib Interaction with acetaminophen will raises the hepatoxicity effect of Sorafenib Interaction with Bevacizumab will increase the toxic effect of Sorafenib

                                                         

Sorafenat 200mg

BODY WORKS FOR THE DRUG SORAFENIB

ABSORPTION

The Sorafenat 200mg bioavailability is 38 to 49% The time to peak serum concentration in 3 hours. High fat meals may decrease the bioavailability of Sorafenib

DISTRIBUTION

The drug Sorafenat 200mg has Human plasma protein bound is 99.5%

METABOLISM

In liver Sorafenat is highly metabolized, it go through oxidative metabolism with the help of CYP3A4 and Glucuronidation by UGT1A9 The main flowing metabolite in serum is pyridine N oxide

ELIMINATION

The dose excreted via feces 77% The dose excreted via urine 19% as glucuronidated metabolites Sorafenat half life is 25 to 48 hours

SAFETY PRECAUTIONS & CONTRAINDICATION

Sorafenat 200mg should not be used, in case of lung cancer, being treated with platinum containing chemo drugs and taxol drugs Sorafenat able to cause heart problems, stop the medicine in case of dizziness, fainting, sweating or shortening of breath Sorafenat causes severe bleeding; care should be taken while getting Sorafenat Stop the Tablet Sorafenat in case of; blood in urine or stools, blood while coughing, Vaginal bleeding Hemorrhage risk QT prolongation. High occurrence of skin toxicity and rashes. Impairs exogenous thyroid suppression. Hypersentivity to the drug and any product of expicients.

                                              

Sorafenat 200mg

SIDE EFFECT

Lymphopenia Neutropenia Hemorrhage Hypertension Neuropathy Anorexia Headache Joint pain Congestive heart failure Acute renal failure Angiodema arrhythmia Interstitial lung disease Post marketing reports: Hypersensitivity reactions: angioedema, anaphylactic reaction Hepatobiliary disorders: hepatitis, hepatic failure and death Musculoskeletal: rhabdomyolysis, osteonecrosis of the jaw Pulmonary: interstitial lung disease

PREGNANCY

Category D: Sorafenat 200 mg can harm to an fetus and cause injury and even death to the unborn baby if you treatment during the 2nd and 3rd trimesters of pregnancy, pregnant women do not use the Sorafenat 200 mgmedicine without the knowledge of your doctor.

LACTATION

The medicine passes into breast milk is not known or could harm a new born baby. Do not use Sorafenat medication, if your breast feeding.

STORAGE

Sorafenat should be store at 25°C (77°F); excursion are allowed between 15°C and 30oC (59°F and 86°F) Protect from moisture, heat and light

MISSED DOSE

If patient missed to take Sorafenat 200mg tablet, they may get advice from medical practitioner (consult) for administration of the missed dose within the time Or the missed dose should be skipped and follow the next dosing schedule Do not have double the dose.

CONTACT US

MAIL ID                :          millionhealthpharmaceuticals@gmail.com

PHONE NO           :           +91-9940472902

WEBSITE              :          https://millionpharma.com/sorafenat.php